Globalization process has a gradually stronger influence on economic development. In this new reality the main indicator is innovation. Various regions of European Union formulate Regional Innovation Strategies (RIS). The goal of this document is to formulate essential elements of regional development strategy. This kind of strategy was created for the Mazovia region. In the document we can read that Mazovia is the most innovative region in Poland, however, it is still far behind regions in highly developed countries. The main strength of Mazovia is the fact that it is a capital region, which means a better access for enterprises to information, important contacts and promotion. Nevertheless, we still can experience many barriers, undermining regular regional development, such as insufficient grants for scientific research or inadequate engagement of public administration to help entrepreneurs.