This paper analyses some of the most important features of postmodernism, determining the way of a modern person’s life, relationship with oneself and, ultimately, with transcendence. One of the main aspects of contemporary society is excessive consumption, in fact relativism, secularism and subjectivism. These phenomena, in their psychological and theological sense, promote the disintegration of the integrity of the human person. This phenomenon becomes very visible in cases of illness, suffering and death. The modern man has lost the harmony between the body, the spirit and the soul, and at the same time the right relationship with God. It does arise in human life between the various dimensions of life: personal self-awareness, family, work, business, work, and other fields. Without faith, postmodernism does not accept man’s inevitability of death, strives to ignore it, or simply flee from it. But this does not give peace to human. The search for the meaning of life and death is in the nature of man, so only believing in a supernatural world, the fostering of spiritual values gives real hope.