Quality of life characterizes the conditions of human existence, the level of satisfaction of needs. Children with disability restrict ability of the families to meet their needs. Parents of these children quite often are limited in their employment and education opportunities, and their resources, they meet with restrictions in all areas if life. Such a situation has developed not only because of the socio-economic situation in the country, but also due to the lack of interest and inadequate support. The aim of the paper is to analyse the family quality of life of the families with disabled children with in regions of Latvia. Empirical data were obtained by structured interviews with 272 families. The research shows that the situation of the families with disabled children differs in different regions of Latvia. Families are supported by the state and municipalities, bet the support in the areas of emotional, physical and social wellbeing does not recompense the influence of special needs of the disabled children on the family quality of life.