In the modern technologized XXI century, the man, surrounded by advancing medicine and improving conditions of life, stumbles upon the disease and the suffering it causes. In such a world full of disease and pain, the Church shows care for the sick in various spiritual ways. On February 11, 1992 St Pope John Paul II officially introduced the annual commemoration of the World Day of the Sick, when the Catholic Church celebrates the liturgy of Our Lady of Lourdes. The World Day of the Sick was first commemorated on 11 February, 1993. John Paul II pronounced thirteen world days of the sick (1993–2005) and addressed them with special letters-messages. Also, John Paul II introduced the tradition of celebrating the World Day of the Sick every year in an important shrine dedicated to the Blessed Virgin Mary of a chosen country. The choice of such shrines dedicated to Mary reveals that the Church is attentive to all suffering physically and spiritually, that the intercession of the Blessed Virgin Mary is called upon in the prayers for health for the sick, and the Mother Mary of Jesus is shown to those caring for the sick as an example of the perfect love of God and neighbour. This article reviews the places of commemoration of the day of the sick associated with the Blessed Virgin Mary in the letters of Pope John Paul II. Discussing the marianism of the places of commemoration of the world days of the sick, the care of Pope John Paul II for the sick and those who perform the service of love for the sick is revealed.