The article builds on the author’ comparative analysis of advantages and disadvantages of regional dimensions (both towards the European Union and the CIS region) of Belarusian foreign policy in framework of multilateralism. The lack of political cooperation since 1997 didn’t affect a lot the dynamic of economic bilateral cooperation between the EU countries and Belarus (since 1995 the EU is the second trade partner for Belarus after Russian Federation). Contrary, it is growing tendency in the CIS region in certain shift from bilateralism to multilateralism in pursuing national security, political and economic interests. Multilateral regional structures, from the Commonwealth of Independent States (CIS), Eurasian Economic Union (EAEU) between Armenia, Belarus, Kazakhstan and Russian Federation (with membership of post-soviet countries) to Shanghai Cooperation Organization (SCO) with membership of Russia and China and observer status of India, Pakistan, Iran and Mongolia and status of dialogue partner for Belarus, Turkey and Shri-Lanka are gaining the power as the essential modes of regional governance, though being still different in integration priorities of member states and fragile in institutions. Existing difficulties should not overshadow gains within those organizations, nor regional dynamism in general by assuming that regional approach towards multilateral cooperation are thought to be more efficient when dealing with local, subregional and regional challenges and problems.