The paper focuses on the currently rather intensive process of the social work professionalisation and proposes to place a greater emphasis on the human dimension, i.e. social worker’s personality as a guarantee of professional success. The occupational burnout syndrome is discussed as a negative subjective circumstance of the profession of social work. The principal traits of the occupational burnout syndrome are revealed, and the dimensions of the occupational burnout syndrome are identified and characterised. On the basis of the works of Lithuanian and foreign researchers on the said subject, the discourse of the occupational burnout syndrome in social work is presented, and the factors that influence the emergence of the phenomenon (both individual and job-related / organisational) in professional activity are discussed. The empirical research by means of the so far the most popular Maslach’s Burnout Inventory (MBI) reveals the effects of the occupational burnout on social worker’s personality, practical activity, and the status of the profession of social work in the society.