In the article there are analysed factors influencing implementation of innovations in Klaipėda city tourism sector. There are discussed the global changes noticeable in Lithuania tourism sector as well. On the basis of conducted in-depth interview with experts there are identified factors, which impede the realization of plans of implementation of innovations in enterprises of the tourism sector such as the following: lack of funding; the problem of attracting investors; unfocused tourism policy, formed in Klaipėda city; not prepared city tourism strategy and its underlying goals; insufficient efforts to attract tourists from neighboring countries. Analysis of the findings showed that with all identified failings there are named technological factors (IT technologies) as the most influencing factors determining implementation of innovations in Lithuania tourism sector, on the basis of which working efficiency may be enhanced and service quality may be improved.