The digital economy has transformed intellectual property protection, challenging traditional patentology paradigms and raising questions

about the evolving role of patent systems in digital innovation ecosystems. This article examines the historical development

of patentology, and analyses how digitalisation has reshaped the functions, scope and economic significance of patents. Using a systematic

literature review (n = 74, 1962–2025), comparative institutional analysis and thematic synthesis, the study explores four key

issues: the historical foundations of patent theory, transformations driven by digital technologies, emerging challenges in innovation

ecosystems, and implications for innovation management and policy. The findings reveal major shifts: software patents redefine patentable

subject matter; standard-essential patents introduce licensing complexities and hold-up risks; and open-source models challenge

traditional exclusivity principles. Patents have evolved from simple exclusion rights into strategic assets in licensing networks,

platform ecosystems and collaborative innovation environments. This study contributes by integrating fragmented perspectives into

a coherent framework that combines technological, institutional and strategic dimensions of patent system transformation. It highlights

the implications for innovation management, regional development and policy reform, arguing that patentology must adopt

interdisciplinary approaches, combining economics, management, technology studies and law, to remain relevant in the digital era.