Innovations and innovative activities are becoming themost important feature of a country or region development. For this reason agreat amount of literature highlights this topic. There are a lot of documents,strategies and programs signed which try to enhance business competitivenessand productivity. Formation of regional policy should make that thisdevelopment will ensure a high quality of life throughout the country. Economicgrowth of countries in encouraging to look for more efficienty, which isdirectly related with innovative entities. The significance of innovations isthe focus of EU regional policy. Although the innovation phenomenon is widelyanalyzed, consistent and specified concept is not formulated. Thus, this paperwill primarily discuss the diversity of innovation concept and interface withthe regional concept. Another part of the work aims to reveal the determinantsof the regional development influencing innovation activities by differentauthor’s approaches. The final section of this paper is to present adoptedmethodological matrix for innovativeness evaluation for regions in Lithuania.In Lithuaniainnovativeness is counted just on a country’s level, no territorial importanceis emphasised. Even though innovations are closely related with regionalpolicy. So the main purpose of this paper is to make methodological basis formore detailed (in a territorial contex) analysis of innovativeness in Lithuania’sregions.