The tasks of the article are: 1) to survey the EU and the Lithuania documents about R&D priorities and initiatives; 2) to analysis the situation of published applications according to date of filing the application; 3) to determine the main R&D smart specialization directions according to published subclasses of International Patent Classification. To achieve these goals the analysis of scientific literature and survey research was used. The study reviewed 2005–2013 the Lithuanian State patent official Gazette and implemented published patent applications situation analysis.