The article presents historical and economic study of Volhynia–Gdańsk regional trade end economic zones during the period from the beginning of the 16th to the middle of the 17th centuries. Change of a dominating role of the Mediterranean economic region, decline of the territories concerned with it, and also processes of economic growth of the countries concerned with Baltic, considerably has affected commodity structure of Volhynia at that time. By these tendencies increases value of Volhynia in geography of the European trade. It was one of barter centres among the East and the West of the Europe. However, already from the middle of the 16th century occurred an active inclusion of the representatives of narrow-mindedness, clergy and gentry to the trade. During this period significantly increases the export to the international market through the Baltic trade and economic region.